Abstract
Described in this report is a systematic study which led to the identification of two new dopamine D2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D2 partial agonists as well as templates for the future design of novel dopaminergic agents.
MeSH terms
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Dopamine Agonists / chemistry*
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Dopamine Agonists / pharmacology
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Phenols / chemical synthesis
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Phenols / chemistry*
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Phenols / pharmacology
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Piperazines / chemical synthesis
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Piperazines / chemistry*
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Piperazines / pharmacology
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Receptors, Dopamine D2 / agonists
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Structure-Activity Relationship
Substances
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3-(2-(benzylamino)ethoxy)phenol
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4-benzyl-1-(3-hydroxyphenyl)piperzine
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Dopamine Agonists
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Phenols
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Piperazines
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Receptors, Dopamine D2